Evaluation of ceruloplasmin in neonatal septicemia.
Indian Pediatr
;
1991 May; 28(5): 489-93
Article
in English
| IMSEAR
| ID: sea-14432
ABSTRACT
Serial serum ceruloplasmin (Cp) levels were estimated in healthy and septicemic neonates, using single radial immunodiffusion. In 25 healthy neonates mean Cp levels were 19.82 mg/dl at birth, 18.20 mg/dl at 12-24 hours, 17.26 mg/dl at 14 +/- 4 days and 17.68 mg/dl at 28 +/- 4 days of life. For the entire neonatal period the mean Cp levels were computed to be 18.24 mg/dl. In 20 culture positive, septicemic neonates, mean Cp levels were 27 mg/dl at onset of disease, 28.65 mg/dl 12-24 hours later and 36.2 mg/dl after 7 +/- 3 days of start of illness (p less than 0.001 for all sampling intervals as compared to healthy group values in first month of life). The mean Cp levels were unaffected by gestational age in both groups. In the septicemic neonates, the mean Cp levels in dying neonates did not differ significantly from recovering neonates for all sampling intervals. It is concluded that estimation of serum Cp levels may help in diagnosis of neonatal septicemia, but it is not useful as an early diagnostic aid or for prognostication.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reference Values
/
Staphylococcal Infections
/
Staphylococcus aureus
/
Time Factors
/
Humans
/
Klebsiella Infections
/
Ceruloplasmin
/
Infant, Newborn
/
Prospective Studies
/
Immunodiffusion
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
1991
Type:
Article
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