Immunophenotyping of mature T/NK cell neoplasm presenting as leukemia.
Indian J Cancer
;
2010 Apr-June; 47(2): 189-193
Article
in English
| IMSEAR
| ID: sea-144328
ABSTRACT
Introduction:
Mature T/NK cell lymphomas (MTNKL) presenting as leukemia are rare and show considerable overlapping of clinical, morphological and immunophenotypic features.AIM:
Critical analysis of the morphology and immunophenotypic profile of MTNKL. Materials andMethods:
We reviewed 380 consecutive cases of mature lymphoid neoplasm that presented as leukemia and were diagnosed on morphology and immunophenotyping of bone marrow and/or peripheral blood samples.Results:
Peripheral blood and bone marrow involvement was seen in all cases. MTNKL constituted 4% (nine cases) of all mature lymphoid neoplasms presenting as leukemia. It included four cases of T-large granular leukemia (T-LGL), two of T-cell prolymphocytic leukemia small cell variant (T-PLL), two of adult T-cell leukemia/lymphoma (ATLL) and one of primary cutaneous gamma delta T-cell lymphoma (PCGDTCL). T-LGL revealed CD4-/CD8+ phenotype in three, and CD4+/CD8+ phenotype in one case. CD56 was absent in all the cases of T-LGL. One case of T- PLL small cell variant showed CD4+/CD8- phenotype, while the other revealed CD4-/CD8+ phenotype. Both cases of ATLL showed CD4+/CD8+/CD25+ phenotype. The single case of PCGDTCL showed CD4-/CD8- phenotype pattern. CD3 and CD5 were expressed in all MTNKL. CD7 was absent in three cases of T-LGL. TCRα/β was performed in three cases of T-LGL and was positive in all. TCRα/β was also seen in both the cases of T-PLL small variant. However, TCRα/β was seen in the single case of PCGDTCL.Conclusion:
Mature nodal T/NK cell neoplasms are rare and MTNKL presenting as leukemia are even rarer. There is an overlap between the immunophenotypic profiles of different MTNKL subtypes and elaborate T/NK cell panels are required for their evaluation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Bone Marrow
/
Aged
/
Female
/
Humans
/
Male
/
Killer Cells, Natural
/
Leukemia-Lymphoma, Adult T-Cell
/
Leukemia, Prolymphocytic, T-Cell
/
Lymphoma, T-Cell
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Indian J Cancer
Year:
2010
Type:
Article
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