Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population.
Indian J Cancer
;
2010 Jul-Sept; 47(3): 317-321
Article
in English
| IMSEAR
| ID: sea-144358
ABSTRACT
Background:
The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer.Objectives:
The objective of this study was to find out the association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. Materials andMethods:
In this study, 48 gastric cancer patients were diagnosed. Genomic DNA was extracted by a salting-out method. The MDR1 polymorphism was studied by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method, using a standard method.Results:
The polymorphic homozygote (T/T) genotype showed significantly an association with the incidence of gastric cancer compared with controls (P < 0.05).Conclusions:
This study suggests that C3435T polymorphism of the MDR1 gene may be associated with gastric cancer in an ethnic Iranian population.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Stomach Neoplasms
/
Aged
/
Female
/
Humans
/
Male
/
DNA Mutational Analysis
/
Adenocarcinoma
/
Ethnicity
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
Type of study:
Incidence study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Cancer
Year:
2010
Type:
Article
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