A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi.
Indian J Cancer
;
2010 Oct-Dec; 47(4): 424-429
Article
in English
| IMSEAR
| ID: sea-144383
ABSTRACT
Context Adenoid cystic carcinoma (ACC) is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim:
To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design andSetting:
Retrospective study at the Department of Radiotherapy. Materials andMethods:
Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology.Results:
There were 8 cases of major salivary gland tumors (47%), of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53%) had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3) and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration.Conclusion:
ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Radiotherapy
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Salivary Gland Neoplasms
/
Retrospective Studies
/
Treatment Outcome
/
Combined Modality Therapy
Type of study:
Observational study
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Cancer
Year:
2010
Type:
Article
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