Helicobacter pylori infection in relation to gastric cancer progression.
Indian J Cancer
;
2011 Jan-Mar; 48(1): 94-98
Article
in English
| IMSEAR
| ID: sea-144418
ABSTRACT
Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Neoplasms
/
Humans
/
Incidence
/
Helicobacter pylori
/
Helicobacter Infections
/
Disease Progression
Type of study:
Incidence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Indian J Cancer
Year:
2011
Type:
Article
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