The Smad family and its role in pancreatic cancer.
Indian J Cancer
;
2011 Jul-Sept; 48(3): 351-360
Article
in English
| IMSEAR
| ID: sea-144494
ABSTRACT
One of the major signaling pathways that determine the tumor aggression and patient outcome in pancreatic cancer is the transforming growth factor-beta (TGF-ß) pathway. It is inactivated at various levels in pancreatic cancer and plays a dual role in tumor initiation and progression. The Smad family of proteins transduce signals from the TGF-ß superfamily ligands that regulate cell proliferation, differentiation and death through activation of receptor serine/threonine kinases. This review discusses the structure, function and regulation of various participating Smad family members, and their individual roles in determining the progression and outcome of pancreatic cancer patients, with a special emphasis on Smad4.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pancreatic Neoplasms
/
Phosphorylation
/
Humans
/
Signal Transduction
/
Cell Differentiation
/
Transforming Growth Factor beta
/
Receptors, Transforming Growth Factor beta
/
Cell Proliferation
/
DNA-Binding Proteins
/
Smad6 Protein
Language:
English
Journal:
Indian J Cancer
Year:
2011
Type:
Article
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