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Recent advances in chronic lymphocytic leukemia.
Indian J Cancer ; 2012 Jan-Mar; 49(1): 137-143
Article in English | IMSEAR | ID: sea-144564
ABSTRACT
Chronic lymphocytic leukemia (CLL) was largely considered to be a disease of slow progression, standard treatment with Chlorambucil and having almost similar prognosis. With the introduction of molecular methods for understanding the disease pathophysiology in CLL there has been a remarkable change in the approach towards the disease. The variation in B-cell receptor response and immunoglobulin heavy chain variable region (IGHV) mutation, genetic aberration and defect in apoptosis and proliferation has had an impact on therapy initiation and prognosis. Early diagnosis of molecular variant is therefore necessary in CLL.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Prognosis / Humans / Immunoglobulin Variable Region / Receptors, Antigen, B-Cell / Leukemia, Lymphocytic, Chronic, B-Cell / Tumor Suppressor Protein p53 / Chromosome Aberrations / Immunoglobulin Heavy Chains / ZAP-70 Protein-Tyrosine Kinase / Lymphocytosis Type of study: Prognostic study / Screening study Language: English Journal: Indian J Cancer Year: 2012 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Prognosis / Humans / Immunoglobulin Variable Region / Receptors, Antigen, B-Cell / Leukemia, Lymphocytic, Chronic, B-Cell / Tumor Suppressor Protein p53 / Chromosome Aberrations / Immunoglobulin Heavy Chains / ZAP-70 Protein-Tyrosine Kinase / Lymphocytosis Type of study: Prognostic study / Screening study Language: English Journal: Indian J Cancer Year: 2012 Type: Article