Stem bark extraction of Ficus bengalensis Linn for anti-inflammatory and analgesic activity in animal models.
Indian J Exp Biol
;
2010 Jan; 48(1): 39-45
Article
in English
| IMSEAR
| ID: sea-144939
ABSTRACT
In the present study, anti-inflammatory and analgesic effect of aqueous extract of Ficus bengalensis (AEFB) and methanolic extract of F. bengalensis (MEFB) was evaluated in animal models. Preliminary results indicated that MEFB treatment possesses significant anti-inflammatory potential as compared to AEFB. The anti-inflammatory activity of MEFB exhibited in both acute (carrageenan induced hind paw edema and acetic acid induced vascular permeability) and sub-chronic (cotton pellet-induced granuloma) models of inflammation was found to be significant. In addition, the extract also showed significant analgesic activity in acetic acid induced writhing. Pretreatment with MEFB during inflammatory condition (both acute and sub-chronic) prevented increase in malondialdehyde (MDA) formation and myeloperoxidase activity in edematous as well as granulomatous tissue. Further, serum marker enzymes (AST, ALT and ALP) increased in inflammatory conditions were also inhibited with MEFB treatment. Hence, the anti-inflammatory activity observed in the present study with MEFB could be attributed largely to its antioxidant and lysosomal membrane stabilizing effects.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Exp Biol
Year:
2010
Type:
Article
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