Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy.
Indian J Med Sci
;
2009 June; 63(6) 244-252
Article
in English
| IMSEAR
| ID: sea-145414
ABSTRACT
Background:
Office hysteroscopy with endometrial biopsy is usually the first investigation for abnormal uterine bleeding and other uterine diseases.Aims:
To evaluate the effect of oral drotaverine with mefenamic acid on pain perception during hysteroscopy and endometrial biopsy and to compare it with that of paracervical block using 1% lignocaine and with that of intravenous sedation using diazepam with pentazocine. Settings andDesign:
Outpatient gynecological department and open randomized trial. Materials andMethods:
One hundred twenty women undergoing hysteroscopy and endometrial biopsy were randomized into 3 groups. Group I received tablet containing drotaverine hydrochloride (80 mg) + mefenamic acid (250 mg), group II received lignocaine paracervically and group III received intravenous diazepam. The intensity of pain during the procedure, 30 and 60 minutes later on visual analog scale (VAS) was assessed. StatisticalAnalysis:
Statistical analysis was performed using Kruskal-Wallis test, with the Bonferroni correction, the t test, and the χ2 test.Results:
Groups were similar in age, parity, vaginal birth or relevant medical history. A statistically significant difference in pain scores was noted among the 3 groups during the procedure (group I, 4.13± 1.28; group II, 5.93± 1.26; group III, 5.58± 1.51), (P< 0.001); as well as 30 minutes later (group I, 1.78± 0.89; group II, 2.53± 0.81; group III, 2.23± 0.94), (P< 0.001) and 60 minutes later (group I, 1.2± 0.46; group II, 1.98± 0.83; group III, 1.68± 0.75), (P< 0.001). VAS at different time intervals among the groups was also statistically significant. No adverse effects were observed.Conclusions:
Oral drotaverine with mefenamic acid is effective in women undergoing hysteroscopy and endometrial biopsy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Papaverine
/
Pentazocine
/
Pain Measurement
/
Female
/
Humans
/
Hysteroscopy
/
Mefenamic Acid
/
Treatment Outcome
/
Anesthetics, Intravenous
/
Adult
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Med Sci
Year:
2009
Type:
Article
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