Epidemiology and genetics of dilated cardiomyopathy in the Indian context.
Indian J Med Sci
;
2009 July; 63(7) 288-296
Article
in English
| IMSEAR
| ID: sea-145422
ABSTRACT
Background:
Dilated cardiomyopathy (DCM) still remains to be a poorly understood and less analyzed group of cardiac-muscle disorders when compared to hypertrophic cardiomyopathy (HCM). Also, the vast clinical heterogeneity among the patients has rendered the small and isolated kindred studies less informative on the genetics and epidemiology of DCM. Aim of the study The study aimed at understanding the epidemiology and genetics of DCMs in the Indian context. Materials and methods/ Statisticalanalysis:
One hundred seven DCM patients and 105 healthy individuals were included in the study for epidemiological and genetic risk factor identification and to fit the possible mode of inheritance. Single's ascertainment methodology for segregation analysis and Penrose frequency estimates were followed to evaluate for the role of specific epidemiological factors in the disease etiology. Chi-square analysis was carried out to interpret the results statistically. Results andConclusion:
Our study suggests that epidemiological factors like gender, age at onset and vegetarian diet in conjunction with sarcomere gene mutations may play a role in the disease expression. Similarly, segregation analysis for the possible mode of inheritance showed a deviation from the autosomal dominant mode of inheritance, strengthening the underlying genetic heterogeneity of DCM.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged
/
Female
/
Humans
/
Male
/
Alcohol Drinking
/
Cardiomyopathy, Dilated
/
Smoking
/
Case-Control Studies
/
Child
/
Child, Preschool
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Sci
Year:
2009
Type:
Article
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