Type 1 leprosy reversal reaction treated with topical tacrolimus along with systemic corticosteroids.
Indian J Med Sci
;
2009 Aug; 63(8) 359-362
Article
in English
| IMSEAR
| ID: sea-145434
ABSTRACT
An 11-year-old black Haitian boy presented with borderline lepromatous leprosy and was treated with rifampicin, dapsone, and clofazimine. After 4 months he developed a severe type 1 reversal reaction without nerve involvement. He was started on prednisolone (1 mg/kg daily). After 4 weeks of treatment with corticosteroids, his condition did not improve and the lesions remained painful. The patient was given a therapeutic trial with twice daily application of topical tacrolimus 0.1% ointment. The result was a dramatic improvement in the skin lesions. The patient's condition was maintained by topical tacrolimus therapy, with healing of all skin lesions. The prednisolone dose was then tapered to zero over a period of 12 weeks. To the best of our knowledge, this is the first report of the efficacy of topical tacrolimus in the treatment of type 1 leprosy reaction.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Male
/
Prednisolone
/
Leprosy, Borderline
/
Child
/
Administration, Topical
/
Tacrolimus
/
Drug Therapy, Combination
/
Glucocorticoids
/
Haiti
Country/Region as subject:
Caribbean
/
Haiti
Language:
English
Journal:
Indian J Med Sci
Year:
2009
Type:
Article
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