Prevalence of Helicobacter pylori and cytotoxin-associated gene A in Iranian patients with non-erosive and erosive reflux disease.
Indian J Med Sci
;
2009 Sept; 63(9) 402-407
Article
in English
| IMSEAR
| ID: sea-145443
ABSTRACT
Background:
The prevalence of Helicobacter pylori (H. pylori) infection and its virulent strain (cytotoxin-associated gene A CagA) has not been evaluated in patients with gastroesophageal reflux disease (GERD) subgroups (erosive and non-erosive) in Iran.AIMS:
This study was conducted to evaluate H. pylori infection and anti-CagA status in GERD. Setting andDesign:
One hundred fifty-four patients (71 male and 83 female; mean age, 42.6± 15.5 years) were evaluated for symptoms - heartburn and acid regurgitation - compatible with GERD. Materials andMethods:
The esophagus was diagnosed endoscopically whether it was with erosion (erosive reflux disease, ERD) or without erosion (non-erosive reflux disease, NERD). Rates of anti-H. pylori and anti-CagA-IgG (immunoglobulin G) antibodies were determined for each subject by ELISA. H. pylori was considered by ELISA if the rapid urease test proved positive. StatisticalAnalysis:
anti-H. pylori and anti-CagA statuses were compared in ERD and NERD patients with and without related IgG antibodies. Mean values and P values were calculated using SPSS (version 12).Results:
The overall prevalence of H. pylori infection was 75.3% (116/154). Anti-CagA antibody was found in 60.3% (70/116) of infected patients. The prevalence of H. pylori infection in patients with NERD and ERD was 81.2% (56/69) and 70.6% (60/85), respectively (OR= 0.56; 95% CI [confidence interval]= 0.26-1.20; P= .14). The prevalence of anti-CagA antibody in infected NERD and ERD patients was 58.9% (33/56) and 61.7% (37/60), respectively (OR= 1.16; 95% CI= 0.49-1.70; P= 0.83).Conclusion:
The results showed that more than 70% of the patients, either NERD or ERD, acquire H. pylori infection. Anti-CagA antibody is also common in patients with reflux disorders in our community.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bacterial Proteins
/
Bacterial Toxins
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Immunoglobulin G
/
Gastroesophageal Reflux
/
Body Mass Index
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Sci
Year:
2009
Type:
Article
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