Ovarian hemangioma with stromal luteinization and HCG-producing mononucleate and multinucleate cells of uncertain histogenesis: A rare co-existence with therapeutic dilemma.
Indian J Pathol Microbiol
;
2012 Oct-Dec 55(4): 509-512
Article
in English
| IMSEAR
| ID: sea-145647
ABSTRACT
A 21 year old female presented with amenorrhea, hirsutism and change in voice along with an elevated serum β-HCG (human chorionic gonadotrophin) level and normal CA-125 level. Laparotomy revealed an enlarged right ovary measuring 6 × 5 × 1 cms with presence of an ovarian hemangioma along with stromal luteinization and HCG producing mononucleate as well as multinucleate cells of uncertain histogenesis on histopathological examination. Immunohistochemistry for inhibin and calretinin were positive in the luteinized component whereas β-HCG and Ki-67 were positive in the multinucleate cell component. The diagnostic rarity and therapeutic dilemma of such a rare mixed tumor within a single ovary has proven to be an exceptional case and an excellent investigative opportunity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ovarian Neoplasms
/
Female
/
Humans
/
Voice Disorders
/
Stromal Cells
/
CA-125 Antigen
/
Luteinization
/
Young Adult
/
Amenorrhea
/
Chorionic Gonadotropin
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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