The low frequency of Y chromosome microdeletions in subfertile males in a Sinhalese population of Sri Lanka.
Indian J Hum Genet
;
2012 Sept; 18(3): 320-325
Article
in English
| IMSEAR
| ID: sea-145854
ABSTRACT
Aims:
This study was designed to determine the prevalence of azoospermia factor (AZF) microdeletions on the Y chromosome in Sri Lankan Sinhalese infertile men with azoospermia and severe oligozoospermia. Settings andDesign:
The patient group was 207 karyotypically normal infertile Sinhalese males. Materials andMethods:
The presence of 13 sequence-tagged site (STS) markers in the AZF region was tested using multiplex polymerase chain reaction (M-PCR). One hundred and twenty unselected men were also studied as a control group.Results:
Three (1.5%) had classic Y chromosome microdeletions in the AZFc sub-region.Conclusions:
These results suggest a much lower Y chromosome microdeletion frequency than previously thought, even among a strictly selected group of sub-fertile males in Sri Lanka.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Hum Genet
Year:
2012
Type:
Article
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