Comparative immunomodulator activity of leaves and bark of albizia lebbeck (LINN.) benth.

ABSTRACT

Adaptability is probably the most distinct characteristics of life which may be defined as sum of all non specific response of the body to any demands made upon it; fundamentally it was a physiological response; primary object of which was to maintain life & to re-establish the normal state. Immunomodulator activity of ethanolic and aqueous extracts of leaves and bark of Albizia lebbeck Benth. were investigated in Swiss albino mice by using swim endurance test and acetic acid induced writhing test model. The ethanolic and aqueous extracts of leaves and bark of Albizia lebbeck were administered to the experimental animals among which the ethanolic extract of Albizia lebbeck leaves have shown to be exhibit strong immunomodulator effect by increasing the swimming or survival time (P<0.001) and also decreased the writhing produced by glacial acetic acid (P<.001). The maximum increase in swimming or survival time was noted in mice receiving test and standard drugs which were significantly more than the control group animals. Test and standard drugs offered maximum protection against acetic acid induced writhes by reducing frequency of writhes per minute.