Design and development of bioadhesive gastro retentive drug delivery system of metoprolol succinate.

ABSTRACT

The conventional dosage forms stay in the stomach for 0.5-2 hours and passes to small intestine and where it gets absorbed within 3-6 hours. Therefore difficult to adjust release retardation and stomach retention of drug for longer period of time. The present research work was attempted to formulate and evaluate the floating tablet with biphasic release of metoprolol succinate. Metoprolol succinate bioahesive gastric drug delivery system was prepared using bioadhesive polymer PEO, Hydrophylic polymer (Carbopol 71G, HPMC E15, Methacrylic acid, Pectin, Carragenan and Guargum) and gas forming agent Sodium bicarbonate. Metoprolol succinate bioahesive gastric drug delivery system was proved to be attained the effective plasma concentration higher than the Marketed formulation. This is due to retaining metoprolol succinate in the stomach (Where it absorbed more) by means of floating and bioadhesive property of the polymer. Metoprolol succinate bioahesive gastric drug delivery system using PEO and HPMC E15 polymers could be effective sustained release formulation.