Evaluating the suitability of prediction equations for lung function in Indian children: a practical approach.
Indian Pediatr
;
2006 Aug; 43(8): 680-98
Article
in English
| IMSEAR
| ID: sea-14707
ABSTRACT
OBJECTIVE:
Although several prediction equations to evaluate peak expiratory flow rate (PEFR) of Indian children are available in literature, clinicians and researchers need to make a logical choice of which equation to use as reference. The aim was to demonstrate a practical approach to making such a logical choice by using prediction equations on our study population.METHODS:
Eighteen linear regression equations generated on Indian children were chosen from available literature. PEFR measured on a Wright peak flow meter on 81 boys and 60 girls, aged between 8 and 13 years, was compared with the predicted values obtained from the equations. Data was systematically analyzed for the extent of over-estimation and under-estimation, correlation between the predicted and measured values and bias and limits of agreement using Bland-Altman plots.RESULTS:
The correlation between observed and predicted values using the eighteen equations ranged between 0.616 and 0.797 (for all P < 0.001). The Bland-Altman plots indicated that for all but three equations in boys and three equations in girls, lower measured values of PEFR were associated with higher predicted values. A final choice of a reference prediction equation was based on a combination of factors which included a high correlation between actual and predicted PEFR values, the bias of the estimate, the limits of agreement and the extent to which equations over or under-estimated PEFR.CONCLUSION:
A practical approach to evaluate the applicability of prediction equations on an independent data set has been demonstrated.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reference Values
/
Respiratory Function Tests
/
Schools
/
Female
/
Humans
/
Male
/
Child
/
Peak Expiratory Flow Rate
/
Total Lung Capacity
/
Vital Capacity
Type of study:
Evaluation studies
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
2006
Type:
Article
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