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Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: A randomized, double-blind placebo controlled trial.
Ann Card Anaesth ; 2013 Jul; 16(3): 180-185
Article in English | IMSEAR | ID: sea-147261
ABSTRACT
Aims and

Objectives:

We evaluated the efficacy of perioperative pregabalin on acute and chronic post-operative pain after off-pump coronary artery bypass (OPCAB) surgery. Materials and

Methods:

Forty patients undergoing elective OPCAB surgery were randomized to pregabalin and control groups. Pregabalin group received 150 mg pregabalin 2 h prior to induction of anesthesia and 75 mg twice daily for 2 post-operative days whereas the control group received placebo at similar timings; pregabalin and placebo were administered by an anesthesiologist blinded to the drugs. Pain scores (visual analogue scale [VAS]) and sedation scores were observed at 0, 4, 6, 12, 24, 36 and 48 h after extubation. Time to extubation, tramadol consumption and side-effects were noted. VAS score was analyzed by Mann-Whitney U test. The analysis of variance test for repeated measures was used for comparison of the means of continuous variables. Group comparisons were made using the Chi-square-test.

Results:

Pain-scores at 6, 12, 24 and 36 h from extubation at rest and at deep breath were less in pregabalin treated patients ( P < 0.05). Tramadol consumption was reduced by 60% in pregabalin group ( P < 0.001). Extent of sedation, extubation times and incidence of nausea were comparable. The effect on chronic post-operative pain was not significant.

Conclusions:

Perioperative pregabalin reduced pain scores at rest and deep breath and reduced consumption of tramadol in the post-operative period without delaying extubation and causing excessive sedation.
Subject(s)

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pain, Postoperative / Female / Humans / Male / Double-Blind Method / Administration, Oral / Perioperative Care / Coronary Artery Bypass, Off-Pump / Acute Pain / Chronic Pain Type of study: Controlled clinical trial Language: English Journal: Ann Card Anaesth Year: 2013 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pain, Postoperative / Female / Humans / Male / Double-Blind Method / Administration, Oral / Perioperative Care / Coronary Artery Bypass, Off-Pump / Acute Pain / Chronic Pain Type of study: Controlled clinical trial Language: English Journal: Ann Card Anaesth Year: 2013 Type: Article