Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: A randomized, double-blind placebo controlled trial.
Ann Card Anaesth
;
2013 Jul; 16(3): 180-185
Article
in English
| IMSEAR
| ID: sea-147261
ABSTRACT
Aims and Objectives:
We evaluated the efficacy of perioperative pregabalin on acute and chronic post-operative pain after off-pump coronary artery bypass (OPCAB) surgery. Materials andMethods:
Forty patients undergoing elective OPCAB surgery were randomized to pregabalin and control groups. Pregabalin group received 150 mg pregabalin 2 h prior to induction of anesthesia and 75 mg twice daily for 2 post-operative days whereas the control group received placebo at similar timings; pregabalin and placebo were administered by an anesthesiologist blinded to the drugs. Pain scores (visual analogue scale [VAS]) and sedation scores were observed at 0, 4, 6, 12, 24, 36 and 48 h after extubation. Time to extubation, tramadol consumption and side-effects were noted. VAS score was analyzed by Mann-Whitney U test. The analysis of variance test for repeated measures was used for comparison of the means of continuous variables. Group comparisons were made using the Chi-square-test.Results:
Pain-scores at 6, 12, 24 and 36 h from extubation at rest and at deep breath were less in pregabalin treated patients ( P < 0.05). Tramadol consumption was reduced by 60% in pregabalin group ( P < 0.001). Extent of sedation, extubation times and incidence of nausea were comparable. The effect on chronic post-operative pain was not significant.Conclusions:
Perioperative pregabalin reduced pain scores at rest and deep breath and reduced consumption of tramadol in the post-operative period without delaying extubation and causing excessive sedation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain, Postoperative
/
Female
/
Humans
/
Male
/
Double-Blind Method
/
Administration, Oral
/
Perioperative Care
/
Coronary Artery Bypass, Off-Pump
/
Acute Pain
/
Chronic Pain
Type of study:
Controlled clinical trial
Language:
English
Journal:
Ann Card Anaesth
Year:
2013
Type:
Article
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