Modulatory effects of Azadirachta indica leaf extract on cutaneous and hepatic biochemical status during promotion phase of DMBA/TPA-induced skin tumorigenesis in mice.

Arora, N; Bansal, M P; Koul, A

Arora, N; Bansal, M P; Koul, A.

Indian J Biochem Biophys ; 2013 Apr; 50(2): 105-113

Article in En | IMSEAR | ID: sea-147293

Subject(s)

9,10-Dimethyl-1,2-benzanthracene/pharmacology; Animals; Antineoplastic Agents/pharmacology; Antioxidants/metabolism; Azadirachta/chemistry; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System/metabolism; Cytochromes b5/metabolism; Gene Expression Regulation, Neoplastic; Glutathione Transferase/metabolism; Lipid Peroxidation; Liver/drug effects; Liver/metabolism; Male; Mice; Micronucleus Tests; Neoplasms, Experimental/chemically induced; Phytotherapy/methods; Plant Extracts/pharmacology; Plant Leaves; Skin/drug effects; Skin/metabolism; Skin Neoplasms/chemically induced; Skin Neoplasms/drug therapy; Tetradecanoylphorbol Acetate/pharmacology; Xenobiotics/chemistry

Key words

Azadirachta indica; Dimethylbenz(a)anthracene; Phorbol-12-myristate-13-acetate; Xenobiotic biotransformation; Antioxidant defense system

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Full text: 1 Index: IMSEAR Main subject: Skin / Skin Neoplasms / Male / Tetradecanoylphorbol Acetate / Plant Extracts / Lipid Peroxidation / Micronucleus Tests / Xenobiotics / Cytochromes b5 / Gene Expression Regulation, Neoplastic Language: En Journal: Indian J Biochem Biophys Year: 2013 Type: Article

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