Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne.
Indian J Dermatol Venereol Leprol
;
2013 Jan-Feb; 79(1): 77-82
Article
in English
| IMSEAR
| ID: sea-147397
ABSTRACT
Background:
Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT.Aims:
To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne.Methods:
Thirty six patients with mild to moderate acne were enrolled. Eighteen patients recieved MAL-PDT and 18 received red light alone in two sessions, 2 weeks apart. Acne grade and lesion counts were assessed by blinded evaluators at baseline, 2, 4 and 10 weeks.Results:
At week 2, clinical improvement from acne grade II-IV to 0-I was observed in 82.3% of MAL-PDT group and 14.2% of red light alone group. Red light alone group had a gradual clinical improvement over time with a 77% response at week 10. In contrast, MAL-PDT group had a rapid clinical improvement with total response at week 10. Both treatments were significantly effective for improving acne lesions. However, MAL-PDT group had a greater response (P < 0.001). Histologically, decreased amounts of sebocytes and lipids along with atrophic sebaceous glands were observed after MAL-PDT.Conclusion:
MAL-PDT has a quicker onset of action with a higher response than red light alone. MAL-PDT may induce a reduction in the size of the sebaceous glands and then long-term acne remission.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Photochemotherapy
/
Severity of Illness Index
/
Female
/
Humans
/
Male
/
Adolescent
/
Treatment Outcome
/
Photosensitizing Agents
/
Acne Vulgaris
/
Adult
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2013
Type:
Article
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