Role of insulin resistance and diet in acne.
Indian J Dermatol Venereol Leprol
;
2013 May-Jun; 79(3): 291-299
Article
in English
| IMSEAR
| ID: sea-147464
ABSTRACT
There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Insulin Resistance
/
Acne Vulgaris
/
Lipogenesis
/
Hyperglycemia
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2013
Type:
Article
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