Newer targeted therapies in psoriasis.
Indian J Dermatol Venereol Leprol
;
2013 July; 79 Suppl(): S47-52
Article
in English
| IMSEAR
| ID: sea-147531
ABSTRACT
Psoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted due to chronicity of the disease and frequent remissions and relapses. Many available systemic therapies, however, are unsuitable for chronic administration due to the risk of cumulative toxicity. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. These include approaches targeting antigen presentation and co-stimulation, T-cell activation and leukocyte adhesion, action on pro-inflammatory mediators, and modulating the cytokine balance. Although only preliminary data are available so far and there is limited data supporting their use, these trials contribute to a further understanding of the disease and will eventually lead to new therapeutic options for psoriasis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Psoriasis
/
Recombinant Fusion Proteins
/
Humans
/
Calcitriol
/
Signal Transduction
/
Cytokines
/
Receptors, Chemokine
/
Molecular Targeted Therapy
/
Antibodies, Monoclonal, Humanized
/
Antigen-Presenting Cells
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2013
Type:
Article
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