Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm.
Indian J Exp Biol
;
2013 Mar; 51(3): 201-207
Article
in English
| IMSEAR
| ID: sea-147583
ABSTRACT
In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Immunohistochemistry
/
Cell Differentiation
/
Cell Line
/
DNA Primers
/
Homeodomain Proteins
/
Gene Expression Regulation, Developmental
/
Cell Lineage
/
Reverse Transcriptase Polymerase Chain Reaction
/
Dithizone
/
Endoderm
Language:
English
Journal:
Indian J Exp Biol
Year:
2013
Type:
Article
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