Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification.
Indian J Cancer
;
2013 July-Sept; 50(3): 164-169
Article
in English
| IMSEAR
| ID: sea-148643
ABSTRACT
BACKGROUND:
Liposarcomas are among the most common soft tissue sarcomas in adulthood.AIM:
The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions. MATERIALS ANDMETHODS:
The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2. STATISTICAL ANALYSIS USED Chi-Square test was applied.RESULTS:
20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01).CONCLUSION:
p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Soft Tissue Neoplasms
/
World Health Organization
/
Female
/
Humans
/
Male
/
Immunohistochemistry
/
Biomarkers, Tumor
/
Tumor Suppressor Protein p53
/
Proto-Oncogene Proteins c-mdm2
/
Liposarcoma
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Cancer
Year:
2013
Type:
Article
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