P-glycoprotein expression as a predictor of response to neoadjuvant chemotherapy in breast cancer.
Indian J Cancer
;
2013 July-Sept; 50(3): 195-199
Article
in English
| IMSEAR
| ID: sea-148648
ABSTRACT
BACKGROUND:
Chemoresistance is an important factor determining the response of tumor to neoadjuvant chemotherapy (NACT). P-glycoprotein (P-gp) expression-mediated drug efflux is one of the mechanisms responsible for multi-drug resistance. Our study was aimed to determine the role of P-gp expression as a predictor of response to NACT in locally advanced breast cancer (LABC) patients. MATERIALS ANDMETHODS:
P-gp expression was performed by real-time quantitative polymerase chain reaction [qRT-PCR] in 76 patients with LABC. Response to adriamycin-based regimen was assessed both clinically and with contrast enhanced computed tomography (CECT) scan before and after NACT. The significance of correlation between tumor and P-gp levels was determined with Chi-square test.RESULTS:
Twenty-one had high and 55 had low P-gp expression. On analyzing P-gp expression with response by World Health Organization (WHO) criteria, statistical significance was obtained (P = 0.038). Similarly, assessment of P-gp expression with response by Response Evaluation in Solid Tumors (RECIST) criteria in 48 patients showed statistical significance (P = 0.0005).CONCLUSION:
This study proves that P-gp expression is a determinant factor in predicting response to NACT. Finally, detection of P-gp expression status before initiation of chemotherapy can be used as a predictive marker for NACT response and will also aid in avoiding the toxic side effects of NACT in non-responders.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Antineoplastic Combined Chemotherapy Protocols
/
Biomarkers, Tumor
/
Chemotherapy, Adjuvant
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Drug Resistance, Neoplasm
/
Adult
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Cancer
Year:
2013
Type:
Article
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