Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast.
Indian J Cancer
;
2013 July-Sept; 50(3): 239-244
Article
in English
| IMSEAR
| ID: sea-148655
ABSTRACT
BACKGROUND:
Aim of this study was to investigate the prognostic significance of CD3+ TILs in infiltrating ductal carcinoma (IDC) of the breast. MATERIALS ANDMETHODS:
Immuno-histochemistry was done with CD3 antibodies in tissue sections of 127 breast cancer patients, and CD3+ intra-tumoral and stromal TILs were counted in relation to clinico-pathological variables.RESULTS:
Intra-tumoral and stromal CD3+ TILs were significantly associated with positive lymph node status (P = 0.006, P = 0.043, respectively) without significant association with age, menopausal status, family history, and hormonal status. The higher CD3 intra-tumoral and stromal counts both showed significant association with good prognosis (P = 0.039, P = 0.044, respectively). The intra-tumoral count was higher than stromal count and was independently associated with disease-free survival in stage I and II cancer (P = 0.021).CONCLUSIONS:
CD3+ TILs may serve as independent marker of good prognosis in IDC breast. The findings of this study need further validation on a larger sample size.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Aged, 80 and over
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Immunohistochemistry
/
Proportional Hazards Models
/
Lymphocytes, Tumor-Infiltrating
/
CD3 Complex
Type of study:
Prognostic study
Limits:
Aged80
Language:
English
Journal:
Indian J Cancer
Year:
2013
Type:
Article
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