Effect of (+)-catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male Wistar rats.
Indian J Exp Biol
;
2013 Oct; 51(10): 823-827
Article
in English
| IMSEAR
| ID: sea-149387
ABSTRACT
Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-catechin hydrate. Plasma non-enzymatic antioxidants viz. α-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson’s disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Water
/
Catechin
/
Rats, Wistar
/
Oxidative Stress
/
Dietary Sucrose
/
Cytoprotection
/
Diet, High-Fat
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2013
Type:
Article
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