Central diabetes insipidus: clinical profile and factors indicating organic etiology in children.
Indian Pediatr
;
2008 Jun; 45(6): 463-8
Article
in English
| IMSEAR
| ID: sea-15013
ABSTRACT
OBJECTIVE:
To evaluate the profile of children with central diabetes insipidus (DI) and identify factors indicating organic etiology.DESIGN:
Retrospective chart review.SETTING:
Tertiary referral hospital.SUBJECTS:
Fifty-nine children with central DI (40 boys, 19 girls).METHODS:
Features of organic and idiopathic central DI were compared using students t test and chi square test. Odds ratio was calculated for factors indicating organic etiology.RESULTS:
Diagnosis included post-operative central DI (13, 22%), central nervous system (CNS) malformations (5, 8.6% holoprosencephaly 4 and hydrocephalus 1), histiocytosis (11, 18.6%), CNS pathology (11, 18.6%; craniopharyngioma 3, empty sella 2, germinoma 2, neuro-tuberculosis 2, arachnoid cyst 1 and glioma 1) and idiopathic central DI (19, 32.2%). Children with organic central DI were diagnosed later (7.8+/- 3.1 years against 5.3+/-2.4 years, P=0.03) and had lower height standard deviation score (-2.7+/-1.0 versus -1.0+/- 1.0, P<0.001) compared to idiopathic group. A greater proportion of children with organic central DI had short stature (81.8% against 10.5%, P <0.001, odds ratio 38.25), neurological features (45.5% against 0%, p 0.009) and anterior pituitary hormone deficiency (81.8% against 5.3%, P<0.001, odds ratio 81) compared to idiopathic group. A combination of short stature and onset after five years of age led to discrimination of organic central DI from idiopathic group in all cases.CONCLUSION:
Organic central DI should be suspected in children presenting after the age of five years with growth retardation and features of anterior pituitary deficiency.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Central Nervous System Diseases
/
Child
/
Child, Preschool
/
Adolescent
/
Diabetes Insipidus, Neurogenic
/
Diabetes Insipidus
/
Infant
Type of study:
Etiology study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
2008
Type:
Article
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