Antidiabetic activity of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl.
Indian J Exp Biol
;
2014 Jan; 52(1): 46-52
Article
in English
| IMSEAR
| ID: sea-150331
ABSTRACT
Glucose uptake by isolated diaphragms of both diabetic, following streptozotocin administration, and non-diabetic animals increased in presence of an oleanane-type triterpenoid saponin isolated from the roots of M. cymbalaria. Insulin release was augmented by the presence of the saponin of M. cymbalaria (1 mg/mL) in rat insulinoma cell line (RIN-5F) pre-exposed to adrenaline (5 µM) and nifedipine (50 µM). Pancreatic histology also indicated considerable quantitative increase in β-cells (75%) when treated with the saponin. The results suggest that the saponin of M. cymbalaria possesses potential antidiabetic activity with respect to insulin secretion, which may be attributed to modulation of calcium channel, and β-cell rejuvenation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Saponins
/
Triterpenes
/
Plant Extracts
/
Calcium Channels
/
Momordica
/
Diabetes Mellitus, Experimental
/
Insulin-Secreting Cells
/
Glucose
/
Hypoglycemic Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
2014
Type:
Article
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