Urolithiasis: Phytotherapy as an adjunct therapy.
Indian J Exp Biol
;
2014 Feb; 52(2): 103-111
Article
in English
| IMSEAR
| ID: sea-150338
ABSTRACT
Role of herbal drugs and medicinal plant extracts in the successful treatment of urolithiasis, classified as the third most common urinary tract diseases is well documented. Ayurvedic plants and their components mediate antilithogenic effects by altering ionic composition of urine, being diuretic, antioxidant or having antimicrobial activity. Therapeutic peptides and proteins have unique place in pharmaceutical biotechnology due to their critical roles in cell biology. The innovation in antilithiatic proteins is that they are anionic, rich in acidic amino acids which make oxalate unavailable by interacting with calcium and have EF Hand domain which is a characteristic feature of various calcium binding protein like calgranulin, osteopontin. The review provides a background on the pathogenesis of urolithiasis and medical treatments. It focusses on the present research evaluating the scientific basis of antilithiatic potential of various plants and role of plant proteins as therapeutic agents thus opening new vista in the management of urolithiasis. Further investigations are required to fully decipher the mode of action of the potent biomolecules so as to exploit their preventive and therapeutic potential.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Plant Extracts
/
Leukocyte L1 Antigen Complex
/
Urolithiasis
/
Osteopontin
/
Medicine, Ayurvedic
/
Phytotherapy
Language:
English
Journal:
Indian J Exp Biol
Year:
2014
Type:
Article
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