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Adverse effects of antiretroviral treatment at a tertiary care hospital in India: a prospective observational study.
Article in English | IMSEAR | ID: sea-150479
ABSTRACT

Background:

Data on adverse drug reactions (ADRs) related to antiretroviral (ARV) use in public health practice are few indicating the need for antiretroviral therapy (ART) safety surveillance in clinical care.

Methods:

143 patients on ART were studied prospectively over a period of two years. All patients were asked to visit the clinic if they developed any symptoms or on a monthly basis. They were screened clinically and investigated suitably for any ADRs.

Results:

143 HIV positive patients were analyzed. At least one ADR was seen in 87 (60.83%) subjects. The most common ADR observed was peripheral neuropathy in 54 (37.76%) patients, followed by lipodystrophy (13.98%), anemia (10.48%) and hyperlipidemia (6.29%). Patients with peripheral neuropathy and lipodystrophy were mainly on stavudine based regimes, while patient with anemia and hyperlipidemia were on zidovudine based regimes.

Conclusions:

In spite of high ADRs, highly active antiretroviral therapy (HAART) is the only answer to HIV/AIDS. To optimize adherence and thus, efficacy of ART, clinicians must focus on preventing adverse effects whenever possible, and distinguish those that are self-limited from those that are potentially serious.

Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study Language: English Year: 2013 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Type of study: Observational study Language: English Year: 2013 Type: Article