Tuberculous meningitis in children: manifestation of an immune compromised state.
Indian Pediatr
;
1993 Oct; 30(10): 1181-6
Article
in English
| IMSEAR
| ID: sea-15073
ABSTRACT
Thirty children in the age group 0-4 years with tuberculous meningitis (TBM) were investigated for their immune status (cell-mediated and humoral). Twenty age, sex and nutritional status matched children were investigated on the same lines, who served as controls. Absolute T cell counts were significantly increased (3126 +/- 1623) (p < 0.01) in TBM, though T cell percentages were comparable (59.8% in TBM versus 54.44% in controls). Leucocyte migration inhibition (LMI) test positivity was high (93%) in TBM patients. Mean LMI index showed a highly statistically significant difference (p < 0.001) between the 'Before-therapy' (0.62 +/- 0.16) and 'During-therapy' (0.77 +/- 0.23) groups in TBM patients. Mantoux test positivity with 1 TU of PPD was low (53.0%) in TBM in comparison to LMIT positivity. In humoral immune response, quantitative function measured by EAC rosettes was not altered. However, there was a significant decrease in the levels of IgA (79.48 +/- 33.78 IU) (p < 0.01), IgG (115.01 +/- 32.56 IU) (p < 0.01) and IgM (148.50 +/- 51.88 IU) (p < 0.05) in TBM patients. There was no significant difference in the complement levels in the TBM and control groups. The results show a well developed CMI response but a poor humoral response in TBM and represent an inverse relationship between the CMI and humoral responses.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculosis, Meningeal
/
Humans
/
Immunoglobulin A
/
Immunoglobulin G
/
Immunoglobulin M
/
Infant, Newborn
/
Cell Migration Inhibition
/
T-Lymphocytes
/
Child, Preschool
/
Infant
Language:
English
Journal:
Indian Pediatr
Year:
1993
Type:
Article
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