Spectrophotometric determination of lacidipine in bulk and tablet dosage form.

ABSTRACT

New, simple, accurate, sensitive, economical, and reproducible UV-spectrophotometric method was developed and validated for the estimation of Lacidipine in bulk and tablet dosage form. Lacidipine shows maximum absorbance at 615.7 nm and linearity (Beer’s Lamberts law) was found to be in the range of 10-70 μg/ml. The apparent molar absorptivity and Sandell’s sensitivity coefficient were found to be 2.84 x 103 L mol-1 cm-1 and 0.16043 indicating the high sensitivity of the proposed methods. The slope, intercept and correlation coefficient were also calculated. Interference of common excipients with the proposed method was also studied and found there was no interference of common excipients with the proposed method. The method was validated by determining its sensitivity, accuracy and precision which proves the suitability of the developed method for the routine estimation of Lacidipine in pharmaceutical formulations.