Effect of Epigallocatechin gallate isolated from Terminalia Bellerica fruit rind on glucoamylase activity in vitro.

ABSTRACT

Chloroform-Ethyl Acetate fraction of Terminalia bellerica fruit rind powder showed maximum antimicrobial activity. This fraction on further purification by column chromatography gave a single spot compound, which after characterisation was found to be Epigallocatechin gallate. Epigallo catechin gallate showed significant antimicrobial activity against E.coli, B. subtilis and S. Aureus. Epigallocatechin gallate inhibits 23.13 to 46.24 % activity of glucoamylase at very low concentrations, therefore may be used as hypoglycaemic agent showing good agreement with the earlier literature.