Comparative Study on HDL-Cholesterol Raising Effects of Atorvastatin and Dehydrolovastatin.

ABSTRACT

HDL-cholesterol raising effect of atorvastatin was compared to that of dehydrolovastatin in an 8-week study in 5 equally-membered groups of pre-acclimatized Sprague-Dawley rats. The first and second groups were normal and hyperlipidemic control, while the others were treated with atorvastatin 14.4 mg, dehydrolovastatin 7.2 mg, and dehydrolovastatin 14.4 mg, per 200 g of mouse body weight per day, respectively. Slightly better effect than atorvastatin\ s could only be achieved by dehydrolovastatin with the same dose.