Antihyperglycemic and Antihyperlipidaemic effect of Polygala rosmarinifolia Wright & Arn on alloxan induced diabetic rats.

ABSTRACT

The ethanol extract of Polygala rosmarinifolia whole plant (Family Polygalaceae) was investigated for its antihyperglycemic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extracts of Polygala rosmarinifolia at a dose of 100 and 200mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Polygala rosmarinifolia whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein – cholesterol (LDL-C), very low density lipoprotein–cholester (VLDL-C), high density lipoprotein – cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats. The ethanol extract of Polygala rosmarinifolia whole plant elicited significant reductions of blood glucose (P<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in serum insulin (P<0.05) in the diabetic rats. From the above results, it is concluded that ethanol extract of Polygala rosmarinifolia possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats.