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Biological activities of [1,2,4] triazolo-[3,4-b],[1,3,4]-thiadiazole-6-yl) (o-tolyamino) methylazetidin-2-one.
Article in English | IMSEAR | ID: sea-151427
ABSTRACT
Synthesis of 4-amino-5-(3-bromophenyl)-4H-1,2,4-triazole-3-thiol (1), 3-(3-bromophenyl) [1,2,4]-triazolo[3,4- b][1,3,4]thiadiazol-6-amine (2), N-substituted benzylidene -3-(3-bromophenyl)-[1,2,4]triazolo-[3,4-b] [1,3,4]- thiadiazole-6-amine (3-7),1-(3-(3-bromophenyl )-[1,2,4]triazolo-[3,4-b] [1,3,4]-thiadiazole-6-yl)-4- substitutedphenyl azetidin-2-one (8-12), 3-(3-(3-bromophenyl)-[1,2,4]triazolo-[3,4-b] [1,3,4]-thiadiazole-6-yl)- 2-phenylthia zolidin-4-one (13-17), 1-(3-(3-bromophenyl)-[1,2,4]triazolo-[3,4-b],[1,3,4]-thiadiazole-6-yl)-4- substi- tutedphenyl-3-((o-tolyamino)methyl)azetidin-2-one (18-27).Among all the synthesized compounds, Mannich products were found to possess wide spectrum of antibactderial and antifungal activities with lesser potency and among the mannich products, 22 and 26 were found most potent compound of the series.

Full text: Available Index: IMSEAR (South-East Asia) Language: English Year: 2012 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Language: English Year: 2012 Type: Article