Modulatory role of Magnesium and Copper Sulphates on Serum Lipid profile and Serum Liver Enzymes in Fructose-induced Diabetic Wistar Rats.

ABSTRACT

The aim of this study is to determine the effect of magnesium and copper sulphates on serum lipid profile and serum liver enzymes in fructose-induced diabetic Wistar rats. Diabetes was induced by administration of 20% (20g/100ml) of fructose dissolved in distilled water and administered to the animals for a period of six (6) weeks. After which the animals were randomly assigned into 4 groups of 6 rats each. Group I served as diabetic negative control were administered 1ml distilled water. Group II were administered Magnesium sulphate (250 mg/kg b w). Group III were administered Copper sulphate (250 mg/kg b w) and Group IV administered Metformin (250 mg/kg b w) served as positive control. All treatments were given orally for a period of seven days. The results obtained showed a statistically significant decrease (p<0.05) in the serum total cholesterol and triglyceride levels in groups administered with 250mg/kg b w of magnesium and copper sulphate when compared to diabetic control group. However, high density lipoprotein serum level was significantly increased (p<0.05) in groups administered with 250mg/kg b w of magnesium and copper sulphate when compared to diabetic control group. The results also showed that magnesium and copper sulphates at dose of 250mg/kg b w produced a significantly decreased (p<0.05) serum levels of liver enzymes (AST, ALT and ALP) in the treated groups when compared to diabetic untreated control group.