Evaluation of endothelial adaptation and parameters of oxidative stress in patients after hemodialysis sessions.

ABSTRACT

This work was focused on the evaluation of parameters of oxidative stress (lipid peroxidation, total thiol groups, non-protein thiol groups, polyphenols and ascorbate) and endothelial adaptation by determining the nitric oxide (NO), high-sensitive C-reactive protein (HS-CRP) and ischemia-modified albumin (IMA) of patients with chronic renal insufficiency submitted to hemodialysis. It was seen a depletion of glutathione, polyphenols and reduced ascorbate, combined with the increase of oxidized ascorbate and lipid peroxidation stress. In addition, was verified the increase of levels of IMA in the plasma. NO showed an evident endothelial protective role due to reduction of levels of HS-CRP, however, did not contribute to increase the levels of IMA. Based on the results, it can be concluded that the patients evaluated in this study presented a clinical situation of oxidative stress. A new study focusing on the prevention of oxidative stress using different experimental models with antioxidants is valuable to improve the life quality of these patients.