Synthesis and antimicrobial evaluation of novel 3-(4,6- diphenyl-6H-1,3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives.

ABSTRACT

A novel series of potentially biologically active 3-(4,6-diphenyl-6H-1,3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives (5a-5k) have been synthesized by the condensation-cyclization reaction of 4,6- diphenyl-6H-1,3-thiazin-2-amine, aromatic aldehyde and thioglycolic acid in polypropylene glycol at 1100C temperature. The structure of the newly synthesized compounds has been established on the basis of their spectral data and elemental analysis. The antimicrobial activity of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus, Bacillus subtilis as a Gram positive bacteria and Escherichia coli, Pseudomonas aeruginosa as a Gram negative bacteria and two pathogenic fungal strains Candida albicans, Aspergillus niger by using the disc diffusion method. The detailed synthesis, spectroscopic data, and antimicrobial screening of synthesized compounds were reported.