Synthesis of Some Novel Heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] Thiadiazole Derivatives as Possible Antimicrobial Agents.

ABSTRACT

A series of 6-aryl-3- (3,4–dialkoxyphenyl) -[1,2,4]triazole [3,4-b][1,3,4] thiadiazole (7a-7o) were synthesized by condensing 4-amino-5-(3,4-dialkoxyphenyl)-4H-[1,2,4]- triazole-3-thiol (6) with various aromatic carboxylic acids in the presence of phosphorous oxychloride through one-pot reaction. The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral studies. All the synthesized compounds were screened for their antimicrobial activity against a variety of microorganisms.