Predictors of Unachieved LDL Levels in Ischemic Stroke Patients Treated with Statins in Yogyakarta Indonesia.

ABSTRACT

Ischemic stroke occurs due to barriers in cerebral vascular. The barriers are manifestation of atherosclerosis formation. Statins are widely used in patients with high level of LDL. The aim of the study was to investigate the factors that influence the Unachieved LDL levels in ischemic stroke patients treated with statin. The study was an analytical research performed using a nested case-control study. The subjects were ischemic stroke patients based on inclusion criteria, and treated with statin. The patients were classified into case group if the result of medical record and the stroke register showed the LDL level of the patients was >100 mg/dL. Whereas the ischemic stroke patients with LDL level <100 mg/dL were classified into control group. Clinical characteristics were investigated in the study including gender, age, comorbid conditions, co-medication, initial LDL levels, amount of comorbid and characteristics of statin treatment. The results were then analyzed using bivariate and multivariate analysis. In the study, 236 patients of ischemic stroke met the inclusion criteria. The results showed that patients with highest initial LDL level (p=0.003; OR=2.618; CI95%=1.398 – 4.904) and patients with more than one comorbid (p=0.006; OR=3.058; CI95%=1.376 – 6.796) had the most significant contributions on Unachieved LDL level. However, gender, age, comorbid conditions, co-medication, and characteristics of statin treatment did not have specific contribution on Unachieved LDL level. The predictor factors that play significant role in Unachieved LDL level in ischemic stroke patients were patients with a very high initial LDL level (≥190 mg/dL) and patients with one more than comorbid.