MDA and antioxidants status in type 2 diabetes mellitus.

ABSTRACT

Background and Objectives: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Depending on the etiology of the Diabetes mellitus, factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. In diabetes, oxidative stress seems caused by both increased production of ROS, sharp reduction in antioxidant defenses and altered cellular redox status. The purpose of this study was to evaluate the oxidative stress in type 2 diabetes mellitus. Methods: The study was conducted on 35 diabetic patients (11 Female /24 Male) with mean age of 52.8±5.4 years. Both the study groups were non-smokers and non-alcoholics and were not suffering from any other chronic disease. MDA and antioxidants status were estimated in both cases (35) and controls (30). Results: Plasma MDA levels in type 2 diabetic patients were found to be significantly higher (p<0.001) than controls, whereas levels of GPx, SOD, CAT, vitamin C and uric acid were significantly lower (p<0.001) in the diabetic patients compared to the control subjects. Conclusion: Diabetic patients were susceptible to oxidative stress and persistent hyperglycemia had an association with free radical-mediated lipid peroxidation. Our study suggests an imbalance between plasma oxidant and antioxidant system in type 2 diabetes mellitus.