Anthropometric changes precede the changes in lipid profile among the healthy young individuals with family history of type 2 diabetes mellitus.

ABSTRACT

Increase in diabetes mellitus (DM) is a major health concern. Offspring’s of subjects with diabetes are known to express various trait characteristics. In the present study, anthropometric and metabolic parameters among healthy offspring’s with (cases, n=50) and without (control, n=50) family history of type 2 DM is compared. Anthropometric measurements, fasting blood sugar and lipid profile were estimated. Cases showed significant increase in their anthropometric measurements than controls and they also demonstrated significant increase in total cholesterol, LDL and decreased HDL and HDL/LDL ratio. Cases were further categorized into two subgroups based on BMI (group 1, BMI=21.55±1.7 kg/m2, group 2, BMI=29.03±4.3 kg/m2). Groups 2, inspite of showing significant increase in their anthropometric measurements than group1 the lipid profiles were comparable. Thus, demonstrating a temporal dissociation between anthropometric and lipid changes, former preceding the later. Therefore, in younger age group, anthropometric measures could be used for risk stratification and as a metric to evaluate the efficacy of preventive intervention.