Role of serum HsCRP as prognostic markers in septicemia in elderly population.

ABSTRACT

Background: Presence of elevated serum HsCRP is strongly associated with morbidity and mortality in diverse populations with sepsis and is a potentially useful biomarker to risk stratify patients with severe sepsis. Aims & Objective: We aimed to study whether the serum HsCRP level at presentation in elderly patients with sepsis correlate with stage of sepsis and ultimate outcome. Material and Methods: In a single centre prospective, observational study conducted in geriatric ward of tertiary care centre, 200 elderly patients (age>60 yrs) with sepsis were included. The primary outcome was 14 days in hospital mortality. Risk factor variable was venous serum HsCRP (mg/l) at presentation. Results: Mortality at 14 days in elderly patients with sepsis was 20%. Mean serum HsCRP in survivor group was 33.42 ± 21.56 while 57.28 ± 25.31 in mortality group (p value <0.001). The mean serum HsCRP level in survivor and non survivors was 32.49 ± 21.45 and 48.05 ± 16.40 in sepsis, 33.61 ± 25.45 and 67.71 ± 21.49 in severe sepsis, 46.62 ± 10.55 and 73.82 ± 32.87 in MODS while 49.0 ± 26.72 and 101.5 ± 9.19 in septic shock group. Conclusion: We conclude that initial high serum HsCRP level was associated with increased mortality independent of etiology of sepsis, it also correlate well with severity of sepsis and serum HsCRP level were high in those with septic shock.