JAK-2V617F Mutation in Acute Leukemia (South Egypt Experience).
Article
in English
| IMSEAR
| ID: sea-153484
ABSTRACT
Aim:
To search for JAK2V617F mutation in patients with acute myeloid and acute lymphoblastic leukemia in south Egypt. StudyDesign:
JAK2V617F mutation detected by amplification refractory mutation system (ARMS) -PCR. Place and Duration of Study Department of clinical pathology and department of medical oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, between December 2010 and December 2012.Method:
We included 90 patients (58 men and 32 women; age range 2-67 years) with denovo acute leukemia (30 acute myeloid leukemia and 60 acute lymphoblastic leukemia), JAK-2 V617F mutation using ARMS-PCR was done for all the patients.Results:
JAK-2 V617F mutation was absent in all of the studied patients.Conclusion:
Our results confirm the finding published previously which reported that JAK2 V617F mutation is very rare or absent in acute leukemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2014
Type:
Article
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