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Insulin secreting and α-glucosidase inhibitory activity of hexane extract of Annona squamosa Linn. in streptozotocin (STZ) induced diabetic rats.
Indian J Exp Biol ; 2014 Jun; 52(6): 623-629
Article in English | IMSEAR | ID: sea-153741
ABSTRACT
The hexane extract of A. squamosa (ASHE) in 100 and 400 mg/kg body weight dose raised the insulin level when compared with Glimepiride (1 mg/kg) and also inhibited α-glucosidase activity when compared with Acarbose (10 mg/kg) in streptozotocin induced diabetic rats. The ASHE significantly reduced peak blood glucose (Gp30) and area under curve (AUC) in diabetic rats in oral glucose (OGTT) and oral sucrose (OSTT) tolerance test, but there was more reduction of Gp30 value than AUC in OSTT. Thus, it can be suggested that the ASHE, has hypoglycemic role at 2 levels, i.e. it acts as secretagogue and also inhibits the intestinal enzymes, responsible for glucose metabolism.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Male / Plant Extracts / Annona / Diabetes Mellitus, Experimental / Glycoside Hydrolase Inhibitors / Hexanes / Hypoglycemic Agents / Insulin / Animals Language: English Journal: Indian J Exp Biol Year: 2014 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Male / Plant Extracts / Annona / Diabetes Mellitus, Experimental / Glycoside Hydrolase Inhibitors / Hexanes / Hypoglycemic Agents / Insulin / Animals Language: English Journal: Indian J Exp Biol Year: 2014 Type: Article