Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers.
Indian J Exp Biol
;
2014 Jul; 52(7): 720-727
Article
in English
| IMSEAR
| ID: sea-153752
ABSTRACT
Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rutin
/
Blood Glucose
/
Body Weight
/
Female
/
Male
/
Glycated Hemoglobin
/
Biomarkers
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
2014
Type:
Article
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