Antinociceptive evaluation of anticonvulsant gabapentin with a conventional nonopioid analgesic in phasic and tonic animal model of acute and chronic pain.
Article
in English
| IMSEAR
| ID: sea-154072
ABSTRACT
Background:
Some antiepileptic drugs have been shown to be clinically efficacious in treatment of neuropathic pain and are being used by clinician.Methods:
This study determined the analgesic effect of gabapentin in rats in biphasic animal pain model of acute and chronic inflammatory pain and compared its potency with a conventional nonopioid analgesic diclofenac.Results:
Per oral administration of gabapentin produced no any marked effect on early phase response of formalin test, but significantly suppressed the late phase response, while diclofenac produced significant anti-nociceptive effect in both phases of formalin test.Conclusion:
Thus, we have observed that gabapentin produced antinociception in second phase of formalin test, which reflects chronic inflammatory pain.
Full text:
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Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2014
Type:
Article
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