In vitro anticancer activity of extracts of Mentha Spp. against human cancer cells.
Indian J Biochem Biophys
;
2014 Oct; 51(5): 416-419
Article
in English
| IMSEAR
| ID: sea-154274
ABSTRACT
In vitro anticancer potential of methanolic and aqueous extracts of whole plants of Mentha arvensis, M. longifolia, M. spicata and M. viridis at concentration of 100 µg/ml was evaluated against eight human cancer cell lines — A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned Mentha Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that Mentha Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Species Specificity
/
Humans
/
Plant Extracts
/
Cell Survival
/
Apoptosis
/
Mentha
/
Dose-Response Relationship, Drug
/
Neoplasms, Experimental
/
Antineoplastic Agents
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2014
Type:
Article
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